منابع مشابه
Leukocyte telomere length and cardiovascular disease in the cardiovascular health study.
The telomere length of replicating somatic cells is inversely correlated with age and has been reported to be associated cross-sectionally with cardiovascular disease (CVD). Leukocyte telomere length, as expressed by mean terminal restriction fragment (TRF) length, was measured in 419 randomly selected participants from the Cardiovascular Health Study, comprising a community-dwelling cohort rec...
متن کاملOriginal Contribution Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
1 Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 2 Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 3 Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, Newark, NJ. 4 Department of Medicine, School of Medicine, University ...
متن کاملTelomere biology and cardiovascular disease.
Accumulation of cellular damage with advancing age leads to atherothrombosis and associated cardiovascular disease. Ageing is also characterized by shortening of the DNA component of telomeres, the specialized genetic segments located at the end of eukaryotic chromosomes that protect them from end-to-end fusions. By inducing genomic instability, replicative senescence and apoptosis, shortening ...
متن کاملLeucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
OBJECTIVE To assess the association between leucocyte telomere length and risk of cardiovascular disease. DESIGN Systematic review and meta-analysis. DATA SOURCES Studies published up to March 2014 identified through searches of Medline, Web of Science, and Embase. ELIGIBILITY CRITERIA Prospective and retrospective studies that reported on associations between leucocyte telomere length an...
متن کاملCellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk.
OBJECTIVE To determine the association between leukocyte telomere length (TL) and atherosclerosis and its clinical sequelae stroke and myocardial infarction. METHODS AND RESULTS Within the scope of the prospective population-based Bruneck Study, leukocyte TL was measured by quantitative polymerase chain reaction in 800 women and men aged 45 to 84 years (in 1995). The manifestation of cardiova...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases
سال: 2010
ISSN: 1875-2136
DOI: 10.1016/j.acvd.2010.08.002